Plain English Meaning
An altitude shown on the approach chart that guarantees you'll clear all terrain and obstacles within a circle around the airport or navaid. It's there as a safety net if you get lost, disoriented, or have an emergency near the airport — fly at or above this altitude and you know you won't hit anything.
Full Definition
Minimum Safe/Sector Altitude (MSA) is an emergency-use altitude depicted on instrument approach charts that provides at least 1,000 feet of obstacle clearance within a defined radius (typically 25 nautical miles) of a specified navigation fix, usually the airport reference point or a primary navaid with the approach. MSAs are published in feet above and may be divided into when terrain or obstacles vary significantly around the .