Plain English Meaning
The navigation signals you're going to use during the flight, and the direction lines you've set on your instruments to follow. Before takeoff, you make sure the right signal is selected and the right direction is dialed in.
Full Definition
The specific radio aids, satellite signals, or other navigation inputs selected for a flight, together with the desired tracks (courses) set on the cockpit navigation instruments. During the before-takeoff check, the pilot confirms that the correct navigation source is chosen for each instrument and that the courses set match the planned route of flight.
Context Anchor
Checked during the when the pilot confirms that the panel, map , or navigation indicator is set up correctly for the planned flight.