Plain English Meaning
It means the pilot is the one accountable for everything that happens on the flight — staying current, staying healthy, staying within their skill level, and making safe choices from before engine start to after shutdown.
Full Definition
The legal and operational obligation of the pilot in command to ensure the safe conduct of a flight, including maintaining personal fitness, currency, proficiency, and sound aeronautical decision-making throughout every phase of operation.
Context Anchor
Seen in preflight planning, weather decisions, go/no-go decisions, and any situation where the pilot must choose the safest course of action.