Plain English Meaning
Flying in the clouds or on an IFR clearance and using a built-in GPS to navigate, where the GPS is the right kind for instrument flying, the database is up to date, and the pilot has followed the required checks before relying on it.
Full Definition
The conduct of an instrument flight rules (IFR) flight using a panel-mounted Global Positioning System (GPS) receiver as the primary means of navigation, where the GPS unit is properly certified for IFR use, the aircraft and installation meet the airworthiness requirements for the intended operation, the receiver's database is current, and the pilot complies with the operating , equipment checks, and (RAIM) or equivalent requirements specified by the for that (, , or ).