Plain English Meaning
Doing what you need to do on the ground so you never end up on a runway you shouldn't be on, and so nothing else ends up on the runway with you when you're using it.
Full Definition
The set of pilot practices used to prevent any unauthorized aircraft, vehicle, or person from entering a runway or its protected area while taxiing, taking off, or landing. It includes thorough preflight planning of taxi routes, careful study of airport diagrams, clear radio communication with ground and tower controllers, strict compliance with hold-short instructions and runway markings, and continuous of the .